On January 17, 2025, the U.S. Environmental Protection Agency (EPA) announced the release of the latest Toxic Substances Control Act (TSCA) Inventory. The TSCA Inventory lists all existing chemical substances manufactured, processed, or imported in the United States under TSCA that do not otherwise qualify for an exemption or exclusion. EPA states that “[t]his biannual update to the public TSCA Inventory is part of EPA’s regular posting of non-confidential TSCA Inventory data.” EPA plans the next regular update of the TSCA Inventory for summer 2025. According to EPA, the TSCA Inventory currently contains 86,847 chemicals, of which 42,495 are active (currently known to be in use) in U.S. commerce. Other updates to the TSCA Inventory include commercial activity data and regulatory flags (e.g., significant new use rules).