As the e-vapor industry evolves, manufacturers must keep up with an expanding legal and regulatory landscape. In addition to designing their products and services to comply, it is important for e-vapor companies to carefully assess their business practices and relationships with employees and business partners so as to best protect their confidential information and intellectual property, minimize their liability when relying on third party vendors, distributors and independent contractors, and ensure that they comply with applicable laws when advertising, marketing, and selling their products and services to consumers. This checklist highlights ten business, advertising, and intellectual property considerations for e-vapor companies doing business in the United States. Other countries may have different (and in some cases more stringent) requirements, so companies should understand their obligations wherever they conduct business.